EXOSOME MICRONEEDLING AND POLYNEUCLEOTIDE SKIN BOOSTER ULTIMATE COMBO

Exosome Microneedling with Polynucleotide Skin Booster Combo

What It Is & Why This Treatment Is Beneficial

Microneedling with Plinest One Polynucleotide Skin Support Booster brings together multiple advanced therapies in a single session for a potent anti-aging and regenerative outcome. Plinest One, a purified salmon-derived polynucleotide, encourages collagen and elastin production, while exosomes—tiny vesicles laden with growth factors—enhance cellular communication and repair. Cold plasma and lymphatic stimulation prime the skin for renewal, while cold hammer cooling calms the skin post-needling. By addressing multiple skin layers in carefully sequenced stages, this approach promotes deep rejuvenation, improved elasticity, and a fresher, more radiant appearance.

What It Does

This multi-step treatment boosts collagen and elastin, softens fine lines and wrinkles, and refines skin tone and texture. Exosomes enhance cellular activity and speed healing, while Plinest One delivers the essential building blocks for tissue repair and regeneration. Cold plasma helps rebalance and prepare the skin environment, lymphatic massage reduces puffiness and improves circulation, and the cold hammer calms and soothes after microneedling. The result is smoother, plumper, hydrated skin with a stronger, more youthful foundation over time.

Microneedling on its own is already powerful, but here it’s part of a wider, layered experience. Each stage—cold plasma, lymphatic massage, targeted cooling, and regenerative boosters—works in sequence to prepare, treat, calm, and restore the skin. It means the results don’t just come from the needling itself, but from how every element is designed to support and amplify the others, creating a treatment that feels more complete and transformative.

How It’s Delivered — Treatment Stages

Stage 1: Cold Plasma

Cold atmospheric plasma is applied to rebalance skin function, reduce bacteria, and enhance receptivity to treatment.

Stage 2: Lymphatic Massage (Jawline Focus)

Gentle lymphatic massage around the jawline stimulates circulation, reduces puffiness, and primes the skin.

Stage 3: Microneedling

Microneedling creates precise micro-channels in the skin to stimulate repair and open pathways for active ingredients.

Stage 4: Exosomes

Exosomes are applied immediately post-needling, reaching deeper layers through the fresh micro-channels to support repair and regeneration.

Stage 5: Cold Hammer

Cooling is applied to calm inflammation, reduce redness, and lock in hydration.

Stage 6: Plinest One Polynucleotide Injections

Targeted mesotherapy-style injections deliver Plinest One into the dermis, providing regenerative support at the cellular level.

Who It’s Not Suitable For

This treatment should be avoided by anyone with active skin infections, open wounds, or a history of keloid scarring. Those with fish or shellfish allergies should also avoid it due to the salmon DNA in Plinest One. Individuals who are pregnant, breastfeeding, or with certain medical conditions should consult a healthcare professional first.

How to Prep & Aftercare

Prep:

• Avoid sun exposure and harsh skincare (e.g., retinols, acids) for 1 week before treatment. SPF everyday.
• For melanated skin, prep with a tyrosinase inhibitor (e.g., tranexamic acid, alpha arbutin, azelaic acid, glutathione) for 2 weeks prior to reduce PIH risk.
• Pause use of tyrosinase inhibitors 3 days before treatment, and resume 5 days post-treatment.

Aftercare:

• Keep skin clean and hydrated, avoid makeup for 24–48 hours.
• Use SPF daily, avoid heavy exercise or sweating for a few days.
• Avoid direct sun exposure for 7 days.
• Continue use of tyrosinase inhibitor after 5 days.

Exosome Microneedling with Plinest One Polynucleotide Skin Booster offers a comprehensive, staged approach to skin rejuvenation. By combining cold plasma, lymphatic massage, microneedling, exosomes, cooling, and targeted polynucleotide injections, this treatment revitalizes the skin at every level—restoring vibrancy, resilience, and a naturally youthful glow.

Because every stage works in synergy, the results feel deeper and more complete than what’s typically expected from microneedling alone. It’s not just about creating channels for actives, but about how the preparation, treatment, and recovery flow together—leaving the skin healthier, calmer, and more luminous from the inside out.